Structure of PDB 2g8n Chain B

Receptor sequence
>2g8nB (length=268) Species: 9606 (Homo sapiens) [Search protein sequence]
PDSAPGQAAVASAYQRFEPRAYLRNNYAPPRGDLCNPNGVGPWKLRCLAQ
TFATGEVSGRTLIDIGSGPTVYQLLSACSHFEDITMTDFLEVNRQELGRW
LQEEPGAFNWSMYSQHACLIEGKGECWQDKERQLRARVKRVLPIDVHQPQ
PLGAGSPAPLPADALVSAFCLEAVSPDLASFQRALDHITTLLRPGGHLLL
IGALEESWYLAGEARLTVVPVSEEEVREALVRSGYKVRDLRTYIMPAHLQ
TGVDDVKGVFFAWAQKVG
3D structure
PDB2g8n Comparison of the Binding of 3-Fluoromethyl-7-sulfonyl-1,2,3,4-tetrahydroisoquinolines with Their Isosteric Sulfonamides to the Active Site of Phenylethanolamine N-Methyltransferase
ChainB
Resolution2.15 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.28: phenylethanolamine N-methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 F83 B Y35 N39 Y40 R44 V53 G54 L58 Y85 Y126 F182 E219 Y222 Y22 N26 Y27 R31 V40 G41 L45 Y72 Y113 F169 E206 Y209 MOAD: Ki=0.063uM
BindingDB: Ki=63nM
BS02 SAH B Y27 Y35 Y40 S80 G81 T83 Y85 D101 F102 L103 N106 D158 V159 A181 F182 C183 V187 Y14 Y22 Y27 S67 G68 T70 Y72 D88 F89 L90 N93 D145 V146 A168 F169 C170 V174
Gene Ontology
Molecular Function
GO:0004603 phenylethanolamine N-methyltransferase activity
GO:0005515 protein binding
GO:0008168 methyltransferase activity
Biological Process
GO:0032259 methylation
GO:0042418 epinephrine biosynthetic process
GO:0042423 catecholamine biosynthetic process
Cellular Component
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2g8n, PDBe:2g8n, PDBj:2g8n
PDBsum2g8n
PubMed16942016
UniProtP11086|PNMT_HUMAN Phenylethanolamine N-methyltransferase (Gene Name=PNMT)

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