Structure of PDB 2g70 Chain B

Receptor sequence
>2g70B (length=265) Species: 9606 (Homo sapiens) [Search protein sequence]
SAPGQAAVASAYQRFEPRAYLRNNYAPPRGDLCNPNGVGPWKLRCLAQTF
ATGEVSGRTLIDIGSGPTVYQLLSACSHFEDITMTDFLEVNRQELGRWLQ
EEPGAFNWSMYSQHACLIEGKGECWQDKERQLRARVKRVLPIDVHQPQPL
GAGSPAPLPADALVSAFCLEAVSPDLASFQRALDHITTLLRPGGHLLLIG
ALEESWYLAGEARLTVVPVSEEEVREALVRSGYKVRDLRTYIMPAHLQTG
VDDVKGVFFAWAQKV
3D structure
PDB2g70 Enzyme Adaptation to Inhibitor Binding: A Cryptic Binding Site in Phenylethanolamine N-Methyltransferase
ChainB
Resolution2.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.28: phenylethanolamine N-methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SAM B Y27 Y35 Y40 G79 S80 T83 Y85 D101 F102 N106 D158 V159 A181 F182 V187 Y222 Y12 Y20 Y25 G64 S65 T68 Y70 D86 F87 N91 D143 V144 A166 F167 V172 Y207
BS02 HNT B N39 Y40 R44 V53 F182 E219 D267 N24 Y25 R29 V38 F167 E204 D252 MOAD: Ki=17nM
BindingDB: Ki=17nM
Gene Ontology
Molecular Function
GO:0004603 phenylethanolamine N-methyltransferase activity
GO:0005515 protein binding
GO:0008168 methyltransferase activity
Biological Process
GO:0032259 methylation
GO:0042418 epinephrine biosynthetic process
GO:0042423 catecholamine biosynthetic process
Cellular Component
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2g70, PDBe:2g70, PDBj:2g70
PDBsum2g70
PubMed17845018
UniProtP11086|PNMT_HUMAN Phenylethanolamine N-methyltransferase (Gene Name=PNMT)

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