Structure of PDB 2g26 Chain B

Receptor sequence
>2g26B (length=329) Species: 9606 (Homo sapiens) [Search protein sequence]
SSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRLYTA
CVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGITVTQM
FGEVTEMPALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDV
FSFYYNRDSELGGQIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVG
SSTLLCEDGCLALVDTGASYISGSTSSIEKLMEALGAKKRLFDYVVKCNE
GPTLPDISFHLGGKEYTLTSADYVFQESYSSKKLCTLAIHAMDIPPPTGP
TWALGATFIRKFYTEFDRRNNRIGFALAR
3D structure
PDB2g26 Ketopiperazine-Based Renin Inhibitors: Optimization of the "C" Ring
ChainB
Resolution2.1 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D33 S36 N38 W40 Y78 D219 A222
Catalytic site (residue number reindexed from 1) D31 S34 N36 W38 Y76 D215 A218
Enzyme Commision number 3.4.23.15: renin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 3LG B D33 G35 W40 P42 Y78 V106 M109 P113 F114 A117 F119 D120 V122 D219 G221 D31 G33 W38 P40 Y76 V104 M107 P111 F112 A115 F117 D118 V120 D215 G217
Gene Ontology
Molecular Function
GO:0004190 aspartic-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:2g26, PDBe:2g26, PDBj:2g26
PDBsum2g26
PubMed16480874
UniProtP00797|RENI_HUMAN Renin (Gene Name=REN)

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