Structure of PDB 2g1n Chain B

Receptor sequence
>2g1nB (length=333) Species: 9606 (Homo sapiens) [Search protein sequence]
SSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRLYTA
CVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGITVTQM
FGEVTEMPALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDV
FSFYYNRDSENSQSLGGQIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKG
VSVGSSTLLCEDGCLALVDTGASYISGSTSSIEKLMEALGAKKRLFDYVV
KCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKKLCTLAIHAMDIPP
PTGPTWALGATFIRKFYTEFDRRNNRIGFALAR
3D structure
PDB2g1n Ketopiperazine-based renin inhibitors: Optimization of the "C" ring
ChainB
Resolution2.9 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D33 S36 N38 W40 Y78 D221 A224
Catalytic site (residue number reindexed from 1) D31 S34 N36 W38 Y76 D219 A222
Enzyme Commision number 3.4.23.15: renin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 1IG B T13 Q14 Y15 V31 D33 Y78 S79 T80 P113 A117 V122 D221 G223 T11 Q12 Y13 V29 D31 Y76 S77 T78 P111 A115 V120 D219 G221
Gene Ontology
Molecular Function
GO:0004190 aspartic-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:2g1n, PDBe:2g1n, PDBj:2g1n
PDBsum2g1n
PubMed16480874
UniProtP00797|RENI_HUMAN Renin (Gene Name=REN)

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