Structure of PDB 2fsz Chain B

Receptor sequence
>2fszB (length=227) Species: 9606 (Homo sapiens) [Search protein sequence]
LDALSPEQLVLTLLEAEPPHVLISRPSAPFTEASMMMSLTKLADKELVHM
ISWAKKIPGFVELSLFDQVRLLESSWMEVLMMGLMWRSIDHPGKLIFAPD
LVLDRDEGKSVEGILEIFDMLLATTSRFRELKLQHKEYLCVKAMILLNSS
MSRKLAHLLNAVTDALVWVIAKSGISSQQQSMRLANLLMLLSHVRHASNK
GMEHLLNMNVVPVYDLLLEMLNAHVLR
3D structure
PDB2fsz A second binding site for hydroxytamoxifen within the coactivator-binding groove of estrogen receptor beta
ChainB
Resolution2.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 OHT B M295 L298 A302 D303 E305 M336 L476 M36 L39 A43 D44 E46 M77 L205 BindingDB: IC50=20nM,Ki=0.16nM,EC50=32nM
BS02 OHT B L306 I310 Q327 V328 L331 E332 W335 L47 I51 Q68 V69 L72 E73 W76 BindingDB: IC50=20nM,Ki=0.16nM,EC50=32nM
External links
PDB RCSB:2fsz, PDBe:2fsz, PDBj:2fsz
PDBsum2fsz
PubMed16782818
UniProtQ92731|ESR2_HUMAN Estrogen receptor beta (Gene Name=ESR2)

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