Structure of PDB 2fq6 Chain B

Receptor sequence
>2fq6B (length=392) Species: 562 (Escherichia coli) [Search protein sequence]
KKLDTQLVNAGRSKKYTLGAVNSVIQRASSLVFDSVEAKKHATRNRANGE
LFYGRRGTLTHFSLQQAMCELEGGAGCVLFPCGAAAVANSILAFIEQGDH
VLMTNTAYEPSQDFCSKILSKLGVTTSWFDPLIGADIVKHLQPNTKIVFL
ESPGSITMEVHDVPAIVAAVRSVVPDAIIMIDNTWAAGVLFKALDFGIDV
SIQAATKYLVGHSDAMIGTAVCNARCWEQLRENAYLMGQMVDADTAYITS
RGLRTLGVRLRQHHESSLKVAEWLAEHPQVARVNHPALPGSKGHEFWKRD
FTGSSGLFSFVLKKKLNNEELANYLDNFSLFSMAYSWGGYESLILANQPE
HIAAIRPQGEIDFSGTLIRLHIGLEDVDDLIADLDAGFARIV
3D structure
PDB2fq6 Inhibitors of bacterial cystathionine beta-lyase: leads for new antimicrobial agents and probes of enzyme structure and function.
ChainB
Resolution1.78 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) R58 Y111 D185 K210
Catalytic site (residue number reindexed from 1) R55 Y108 D182 K207
Enzyme Commision number 4.4.1.13: cysteine-S-conjugate beta-lyase.
4.4.1.28: L-cysteine desulfidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 P3F B C85 G86 A87 Y111 P113 D185 A207 T209 K210 M219 Y338 S339 W340 R372 C82 G83 A84 Y108 P110 D182 A204 T206 K207 M216 Y335 S336 W337 R369
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0008784 alanine racemase activity
GO:0016829 lyase activity
GO:0030170 pyridoxal phosphate binding
GO:0042802 identical protein binding
GO:0047804 cysteine-S-conjugate beta-lyase activity
GO:0080146 L-cysteine desulfhydrase activity
Biological Process
GO:0006520 amino acid metabolic process
GO:0009086 methionine biosynthetic process
GO:0019346 transsulfuration
GO:0019450 L-cysteine catabolic process to pyruvate
GO:0051289 protein homotetramerization
Cellular Component
GO:0005737 cytoplasm
GO:0032991 protein-containing complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2fq6, PDBe:2fq6, PDBj:2fq6
PDBsum2fq6
PubMed17300162
UniProtP06721|METC_ECOLI Cystathionine beta-lyase MetC (Gene Name=metC)

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