Structure of PDB 2fhx Chain B

Receptor sequence
>2fhxB (length=245) Species: 287 (Pseudomonas aeruginosa) [Search protein sequence]
DHVDLPYNLTATKIDSDVFVVTDRDFYSSNVLVAKMLDGTVVIVSSPFEN
LGTQTLMDWVAKTMKPKKVVAINTHFHLDGTGGNEIYKKMGAETWSSDLT
KQLRLEENKKDRIKAAEFYKNEDLKRRILSSHPVPADNVFDLKQGKVFSF
SNELVEVSFPGPAHSPDNVVVYFPKKKLLFGGCMIKPKELGYLGDANVKA
WPDSARRLKKFDAKIVIPGHGEWGGPEMVNKTIKVAEKAVGEMRL
3D structure
PDB2fhx Crystal Structure of Pseudomonas aeruginosa SPM-1 Provides Insights into Variable Zinc Affinity of Metallo-beta-lactamases.
ChainB
Resolution1.9 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H116 H118 D120 H196 C221 K224 Y233 H263
Catalytic site (residue number reindexed from 1) H75 H77 D79 H164 C183 K186 Y192 H220
Enzyme Commision number 3.5.2.6: beta-lactamase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN B H116 H118 H196 H75 H77 H164
BS02 AZI B H196 C221 K224 Y233 H164 C183 K186 Y192
Gene Ontology
Molecular Function
GO:0008270 zinc ion binding
GO:0008800 beta-lactamase activity
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
Biological Process
GO:0017001 antibiotic catabolic process
GO:0046677 response to antibiotic
Cellular Component
GO:0042597 periplasmic space

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Cellular Component
External links
PDB RCSB:2fhx, PDBe:2fhx, PDBj:2fhx
PDBsum2fhx
PubMed16460758
UniProtQ8G9Q0

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