Structure of PDB 2fdd Chain B

Receptor sequence

>2fddB (length=99) Species: 11676 (Human immunodeficiency virus 1) [Search protein sequence]

PQITLWQRPIVTIKIGGQQREALLDTGADDTVLEDINLPGRWKPKIIGGV
GGFVKVRQYDQVPIEICGHKVIGTVLVGPTPANIIGRNLMTQIGCTLNF

3D structure

PDB

2fdd Ultra-potent P1 modified arylsulfonamide HIV protease inhibitors: The discovery of GW0385.

Chain

Resolution

1.58 Å

3D
structure

Catalytic site residues are labeled in the structure
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Enzymatic activity

Catalytic site (original residue number in PDB)	D25 T26 G27
Catalytic site (residue number reindexed from 1)	D25 T26 G27
Enzyme Commision number	3.4.23.16: HIV-1 retropepsin.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	385	B	D25 G27 A28 D30 P81 A82 I84	D25 G27 A28 D30 P81 A82 I84	MOAD: ic50=4.8nM PDBbind-CN: -logKd/Ki=8.32,IC50=4.8nM

Gene Ontology

	Molecular Function
GO:0004190	aspartic-type endopeptidase activity

	Biological Process
GO:0006508	proteolysis

External links