Structure of PDB 2fav Chain B

Receptor sequence
>2favB (length=171) [Search protein sequence]
PVNQFTGYLKLTDNVAIKCVDIVKEAQSANPMVIVNAANIHLKHGGGVAG
ALNKATNGAMQKESDDYIKLNGPLTVGGSCLLSGHNLAKKCLHVVGPNLN
AGEDIQLLKAAYENFNSQDILLAPLLSAGIFGAKPLQSLQVCVQTVRTQV
YIAVNDKALYEQVVMDYLDNL
3D structure
PDB2fav Structural and functional basis for ADP-ribose and poly(ADP-ribose) binding by viral macro domains.
ChainB
Resolution1.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.-
2.1.1.56: mRNA (guanine-N(7))-methyltransferase.
2.1.1.57: methyltransferase cap1.
2.7.7.48: RNA-directed RNA polymerase.
2.7.7.50: mRNA guanylyltransferase.
3.1.13.-
3.4.19.12: ubiquitinyl hydrolase 1.
3.4.22.-
3.4.22.69: SARS coronavirus main proteinase.
3.6.4.12: DNA helicase.
3.6.4.13: RNA helicase.
4.6.1.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 APR B D23 I24 A39 N41 G49 V50 L127 S129 A130 G131 I132 F133 N157 D21 I22 A37 N39 G47 V48 L125 S127 A128 G129 I130 F131 N155 MOAD: Kd=24uM
External links
PDB RCSB:2fav, PDBe:2fav, PDBj:2fav
PDBsum2fav
PubMed16912299
UniProtP0C6X7|R1AB_SARS Replicase polyprotein 1ab (Gene Name=rep)

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