Structure of PDB 2fap Chain B

Receptor sequence
>2fapB (length=94) Species: 9606 (Homo sapiens) [Search protein sequence]
VAILWHEMWHEGLEEASRLYFGERNVKGMFEVLEPLHAMMERGPQTLKET
SFNQAYGRDLMEAQEWCRKYMKSGNVKDLTQAWDLYYHVFRRIS
3D structure
PDB2fap Refined structure of the FKBP12-rapamycin-FRB ternary complex at 2.2 A resolution.
ChainB
Resolution2.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 RAD B L2031 S2035 R2036 F2039 D2102 Y2105 F2108 L13 S17 R18 F21 D84 Y87 F90
Gene Ontology
Molecular Function
GO:0044877 protein-containing complex binding

View graph for
Molecular Function
External links
PDB RCSB:2fap, PDBe:2fap, PDBj:2fap
PDBsum2fap
PubMed10089303
UniProtP42345|MTOR_HUMAN Serine/threonine-protein kinase mTOR (Gene Name=MTOR)

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