Structure of PDB 2fai Chain B

Receptor sequence
>2faiB (length=245) Species: 9606 (Homo sapiens) [Search protein sequence]
NSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRE
LVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLL
FAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIIL
LNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQR
LAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHR
3D structure
PDB2fai Identification of ligands with bicyclic scaffolds provides insights into mechanisms of estrogen receptor subtype selectivity.
ChainB
Resolution2.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B I358 K362 L372 V376 E380 D538 L539 M543 I55 K59 L69 V73 E77 D235 L236 M240
BS02 459 B M343 E353 F404 M421 G521 H524 L525 M40 E50 F101 M118 G218 H221 L222 MOAD: Ki=570nM
External links
PDB RCSB:2fai, PDBe:2fai, PDBj:2fai
PDBsum2fai
PubMed16648639
UniProtP03372|ESR1_HUMAN Estrogen receptor (Gene Name=ESR1)

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