Structure of PDB 2f90 Chain B

Receptor sequence
>2f90B (length=253) Species: 9606 (Homo sapiens) [Search protein sequence]
KYKLIMLRHGEGAWNKENRFCSWVDQKLNSEGMEEARNCGKQLKALNFEF
DLVFTSVLNRSIHTAWLILEELGQEWVPVESSWRLNERHYGALIGLNREQ
MALNHGEEQVRLWRRSYNVTPPPIEESHPYYQEIYNDRRYKVCDVPLDQL
PRSESLKDVLERLLPYWNERIAPEVLRGKTILISAHGNSSRALLKHLEGI
SDEDIINITLPTGVPILLELDENLRAVGPHQFLGDQEAIQAAIKKVEDQG
KVK
3D structure
PDB2f90 Seeing the process of histidine phosphorylation in human bisphosphoglycerate mutase
ChainB
Resolution2.0 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H11 R62 E89 H188
Catalytic site (residue number reindexed from 1) H9 R60 E87 H186
Enzyme Commision number 5.4.2.11: phosphoglycerate mutase (2,3-diphosphoglycerate-dependent).
5.4.2.4: bisphosphoglycerate mutase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ALF B R10 H11 N17 R62 E89 H188 G189 R8 H9 N15 R60 E87 H186 G187
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004082 bisphosphoglycerate mutase activity
GO:0004619 phosphoglycerate mutase activity
GO:0005515 protein binding
GO:0016787 hydrolase activity
GO:0016853 isomerase activity
GO:0016868 intramolecular phosphotransferase activity
GO:0046538 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006096 glycolytic process
GO:0006753 nucleoside phosphate metabolic process
GO:0007585 respiratory gaseous exchange by respiratory system
GO:0015671 oxygen transport
GO:0033554 cellular response to stress
GO:0042832 defense response to protozoan
GO:0048821 erythrocyte development
GO:0060856 establishment of blood-brain barrier
GO:0150076 neuroinflammatory response
GO:1901136 carbohydrate derivative catabolic process
Cellular Component
GO:0005829 cytosol
GO:0070062 extracellular exosome

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Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:2f90, PDBe:2f90, PDBj:2f90
PDBsum2f90
PubMed17052986
UniProtP07738|PMGE_HUMAN Bisphosphoglycerate mutase (Gene Name=BPGM)

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