Structure of PDB 2f35 Chain B

Receptor sequence
>2f35B (length=251) Species: 10116 (Rattus norvegicus) [Search protein sequence]
RTLIVTTILEEPYVMYRKSDKPLYGNDRFEGYCLDLLKELSNILGFLYDV
KLVPDGKYGAQNDKGEWNGMVKELIDHRADLAVAPLTITYVREKVIDFSK
PFMTLGISILYRKGTPIDSADDLAKQTKIEYGAVRDGSTMTFFKKSKIST
YEKMWAFMSSRQQSALVKNSDEGIQRVLTTDYALLMESTSIEYVTQRNCN
LTQIGGLIDSKGYGVGTPIGSPYRDKITIAILQLQEEGKLHMMKEKWWRG
N
3D structure
PDB2f35 Crystal structures of the kainate receptor GluR5 ligand binding core dimer with novel GluR5-selective antagonists.
ChainB
Resolution1.87 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 UBC B Y61 P88 L89 T90 R95 V137 G140 S141 T142 Y58 P85 L86 T87 R92 V134 G137 S138 T139 MOAD: Kd=3.94uM
BindingDB: Kd=402nM
Gene Ontology
Molecular Function
GO:0015276 ligand-gated monoatomic ion channel activity
Cellular Component
GO:0016020 membrane

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Molecular Function
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Cellular Component
External links
PDB RCSB:2f35, PDBe:2f35, PDBj:2f35
PDBsum2f35
PubMed16540562
UniProtP22756|GRIK1_RAT Glutamate receptor ionotropic, kainate 1 (Gene Name=Grik1)

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