Structure of PDB 2f17 Chain B

Receptor sequence
>2f17B (length=243) Species: 10090 (Mus musculus) [Search protein sequence]
MEHAFTPLEPLLPTGNLKYCLVVLNQPLDARFRHLWKKALLRACADGGAN
HLYDLTEGERESFLPEFVSGDFDSIRPEVKEYYTKKGCDLISTPDQDHTD
FTKCLQVLQRKIEEKELQVDVIVTLGGLGGRFDQIMASVNTLFQATHITP
VPIIIIQKDSLIYLLQPGKHRLHVDTGMEGSWCGLIPVGQPCNQVTTTGL
KWNLTNDVLGFGTLVSTSNTYDGSGLVTVETDHPLLWTMAIKS
3D structure
PDB2f17 Pyrithiamine as a substrate for thiamine pyrophosphokinase
ChainB
Resolution2.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.6.2: thiamine diphosphokinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PYI B W202 T217 S218 W202 T217 S218
BS02 MG B D46 D71 D100 D46 D71 D100
BS03 PYI B Q96 D97 H98 T99 D100 Q96 D97 H98 T99 D100
Gene Ontology
Molecular Function
GO:0004788 thiamine diphosphokinase activity
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0030975 thiamine binding
GO:0042802 identical protein binding
GO:0141200 UTP thiamine diphosphokinase activity
Biological Process
GO:0006772 thiamine metabolic process
GO:0009229 thiamine diphosphate biosynthetic process
GO:0010510 regulation of acetyl-CoA biosynthetic process from pyruvate
GO:0016310 phosphorylation
GO:0042723 thiamine-containing compound metabolic process
Cellular Component
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2f17, PDBe:2f17, PDBj:2f17
PDBsum2f17
PubMed16365036
UniProtQ9R0M5|TPK1_MOUSE Thiamine pyrophosphokinase 1 (Gene Name=Tpk1)

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