Structure of PDB 2epn Chain B

Receptor sequence
>2epnB (length=623) Species: 1302 (Streptococcus gordonii) [Search protein sequence]
ATFLGLSSKQEKALVRLDKYLNLGEIAVSLVATSIKVEGRQGYYQVSYKQ
PHQLYRALALLSAALRSGQDEVQIEEEAAYEDLAYMADCSRNAVLNLSSA
KKMIEVLALMGYSTFELYMEDTYEIENQPYFGYFRGRYTVAELQEIEDYA
ADFDMSFVPCIQTLAHLSAFVKWGIKEVQELRDVEDILLIGEEKVYDLIE
GMFQTMAHLHTRKINIGMDEAHLVGLGRYLIKHGFQNRSLLMCQHLERVL
DIADKYGFNCQMWSDMFFKLMSADGQYDRDVEIPEETRVYLDRLKERVTL
VYWDYYQDSEEKYNRNFQNHHKISQDIAFAGGAWKWIGFTPHNHFSRLVA
IEANKACRKNQVKEVIVTGWGDNGGETSQFSVLPALQIWAELAYRNDLKK
VSEHFLVSTGLDFDDFMKIDLANLLPDLPDNLSGINPNRYVLYQDVLCPL
LEQHIRPEKDKQHFASSAQQLGEISKRAGEYAYIFETQAQLNALLALKIS
ITSGIQKAYRNGDKEHLSALAEKDFPQLYQMVEDFSDQFSRQWQQENKIF
GLDTIDIRFGGLLKRIKRAQERLEQFISGQIDCVEELEQEILPFNDFYKD
QGLTATTANQWHLIATASTIYTT
3D structure
PDB2epn Structure of N-acetyl-beta-D-glucosaminidase (GcnA) from the Endocarditis Pathogen Streptococcus gordonii and its Complex with the Mechanism-based Inhibitor NAG-thiazoline
ChainB
Resolution1.61 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.2.1.52: beta-N-acetylhexosaminidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NGT B R95 H170 D223 E224 W267 W307 Y309 W340 W374 D376 R91 H166 D219 E220 W263 W303 Y305 W336 W370 D372 MOAD: Ki=60nM
PDBbind-CN: -logKd/Ki=7.22,Ki=60nM
Gene Ontology
Molecular Function
GO:0004563 beta-N-acetylhexosaminidase activity
GO:0015929 hexosaminidase activity
GO:0016798 hydrolase activity, acting on glycosyl bonds

View graph for
Molecular Function
External links
PDB RCSB:2epn, PDBe:2epn, PDBj:2epn
PDBsum2epn
PubMed18237743
UniProtQ6ST21

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