Structure of PDB 2ejv Chain B

Receptor sequence
>2ejvB (length=343) Species: 300852 (Thermus thermophilus HB8) [Search protein sequence]
MRALAKLAPEEGLTLVDRPVPEPGPGEILVRVEAASICGTDLHIWKWDAW
ARGRIRPPLVTGHEFSGVVEAVGPGVRRPQVGDHVSLESHIVCHACPACR
TGNYHVCLNTQILGVDRDGGFAEYVVVPAENAWVNPKDLPFEVAAILEPF
GNAVHTVYAGSGVSGKSVLITGAGPIGLMAAMVVRASGAGPILVSDPNPY
RLAFARPYADRLVNPLEEDLLEVVRRVTGSGVEVLLEFSGNEAAIHQGLM
ALIPGGEARILGIPSDPIRFDLAGELVMRGITAFGIAGRRLWQTWMQGTA
LVYSGRVDLSPLLTHRLPLSRYREAFGLLASGQAVKVILDPKA
3D structure
PDB2ejv Crystal structure of threonine 3-dehydrogenase
ChainB
Resolution2.55 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) C38 G39 T40 H43 H63 E64 C93 C96 C99 C107 Q111 P149 A153 K336
Catalytic site (residue number reindexed from 1) C38 G39 T40 H43 H63 E64 C93 C96 C99 C107 Q111 P149 A153 K336
Enzyme Commision number 1.1.1.103: L-threonine 3-dehydrogenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN B C38 H63 E64 C38 H63 E64
BS02 ZN B C96 C99 C107 C96 C99 C107
BS03 NAD B N152 G174 P175 I176 S195 D196 P197 R201 F238 S239 N241 A244 L261 I263 N152 G174 P175 I176 S195 D196 P197 R201 F238 S239 N241 A244 L261 I263
Gene Ontology
Molecular Function
GO:0008270 zinc ion binding
GO:0008743 L-threonine 3-dehydrogenase activity
GO:0016491 oxidoreductase activity
GO:0046872 metal ion binding
Biological Process
GO:0006567 threonine catabolic process
GO:0019518 L-threonine catabolic process to glycine
Cellular Component
GO:0005737 cytoplasm

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Cellular Component
External links
PDB RCSB:2ejv, PDBe:2ejv, PDBj:2ejv
PDBsum2ejv
PubMed
UniProtQ5SKS4|TDH_THET8 L-threonine 3-dehydrogenase (Gene Name=tdh)

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