Structure of PDB 2eb1 Chain B

Receptor sequence
>2eb1B (length=170) Species: 9606 (Homo sapiens) [Search protein sequence]
NHLISGFENFEKKINYRFKNKAYLLQAFTHASYHYNTITDCYQRLEFLGD
AILDYLITKHLYEDPRQHSPGVLTDLRSALVNNTIFASLAVKYDYHKYFK
AVSPELFHVIDDFVQFQLEKEDIEVPKAMGDIFESLAGAIYMDSGMSLET
VWQVYYPMMRPLIEKFSANV
3D structure
PDB2eb1 Homodimeric Structure and Double-stranded RNA Cleavage Activity of the C-terminal RNase III Domain of Human Dicer
ChainB
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.26.3: ribonuclease III.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG B E47 D152 E155 E46 D131 E134
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0004525 ribonuclease III activity
Biological Process
GO:0006396 RNA processing
GO:0030422 siRNA processing
GO:0031054 pre-miRNA processing

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Molecular Function
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Biological Process
External links
PDB RCSB:2eb1, PDBe:2eb1, PDBj:2eb1
PDBsum2eb1
PubMed17920623
UniProtQ9UPY3|DICER_HUMAN Endoribonuclease Dicer (Gene Name=DICER1)

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