Structure of PDB 2e9e Chain B

Receptor sequence

>2e9eB (length=595) Species: 9925 (Capra hircus)

SWEVGCGAPVPLVTCDEQSPYRTITGDCNNRRSPALGAANRALARWLPAE
YEDGLAVPFGWTQRKTRNGFRVPLAREVSNKIVGYLDEEGVLDQNRSLLF
MQWGQIVDHDLDFAPETELGSSEHSKVQCEEYCVQGDECFPIMFPKNDPK
LKTQGKCMPFFRAGFVCPTPPYQSLARDQINAVTSFLDASLVYGSEPSLA
SRLRNLSSPLGLMAVNQEAWDHGLAYPPFNNVKPSPCEFINTTAHVPCFQ
AGDSRASEQILLATVHTLLLREHNRLARELKRLNPHWDGEMLYQEARKIL
GAFIQIITFRDYLPIVLGSEMQKWIPPYQGYNNSVDPRISNVFTFAFRFG
HMEVPSTVSRLDENYQPWGPEAELPLHTLFFNTWRIIKDGGIDPLVRGLL
AKNSKLMNQNKMVTSELRNKLFQPTHKVHGFDLAAINLQRCRDHGMPGYN
SWRGFCGLSQPKTLKGLQAVLKNKVLAKKLLDLYKTPDNIDIWIGGNAEP
MVERGRVGPLLACLLGRQFQQIRDGDRFWWENPGVFTEKQRDSLQKVSFS
RLICDNTHITKVPLHAFQANNYPHDFVDCSAVDKLDLSPWASREN

3D structure

• PDB: 2e9e Crystal structure of the complex of goat lactoperoxidase with Nitrate at 3.25 A resolution
• Chain: B
• Resolution: 3.25 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): Q105 D108 H109 D110 T184 F186 D188 S190 R255 E258 H351
• Catalytic site (residue number reindexed from 1): Q105 D108 H109 D110 T184 F186 D188 S190 R255 E258 H351
• Enzyme Commision number: 1.11.1.7: peroxidase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	CO3	B	R96 R506	R96 R506
BS02	CA	B	D110 T184 F186 D188 S190	D110 T184 F186 D188 S190
BS03	HEM	B	M101 G104 Q105 D108 D112 E258 T344 F347 R348 G350 H351 V354 I436 R440	M101 G104 Q105 D108 D112 E258 T344 F347 R348 G350 H351 V354 I436 R440
BS04	OSM	B	Q105 H109	Q105 H109

Gene Ontology

Molecular Function

• GO:0004601 peroxidase activity
• GO:0020037 heme binding

Biological Process

• GO:0006979 response to oxidative stress

External links

• PDB: RCSB:2e9e, PDBe:2e9e, PDBj:2e9e
• PDBsum: 2e9e
• UniProt: A0A452E9Y6|PERL_CAPHI Lactoperoxidase (Gene Name=LPO)