Structure of PDB 2dwc Chain B

Receptor sequence
>2dwcB (length=409) Species: 70601 (Pyrococcus horikoshii OT3) [Search protein sequence]
VVMIKLRDELGTATTDSAQKILLLGSGELGKEIAIEAQRLGVEVVAVDRY
ANAPAMQVAHRSYVGNMMDKDFLWSVVEREKPDAIIPEIEAINLDALFEF
EKDGYFVVPNARATWIAMHRERLRETLVKEAKVPTSRYMYATTLDELYEA
CEKIGYPCHTKAIMSGSYFVKGPEDIPKAWEEEKIIVEEHIDFDVEVTEL
AVRHFDENGEIVTTFPKPVGHYQIDGDYHASWQPAEISEKAEREVYRIAK
RITDVLGGLGIFGVEMFVKGDKVWANEVSPRPHDTGMVTLASHPPGFSEF
ALHLRAVLGLPIPGEWVDGYRLFPMLIPAATHVIKAKVSGYSPRFRGLVK
ALSVPNATVRLFGKPEAYVGRRLGIALAWDKDVEVAKRKAEMVAHMIELR
TRSSDWHDQ
3D structure
PDB2dwc Crystal structure of Probable phosphoribosylglycinamide formyl transferase from Pyrococcus horikoshii OT3 complexed with ADP
ChainB
Resolution1.7 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) E279 E291 D298 T299 R386
Catalytic site (residue number reindexed from 1) E265 E277 D284 T285 R372
Enzyme Commision number 6.3.1.21: phosphoribosylglycinamide formyltransferase 2.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP B R121 H160 K162 H204 I205 F207 E210 F281 E291 R120 H159 K161 H190 I191 F193 E196 F267 E277
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0003824 catalytic activity
GO:0004644 phosphoribosylglycinamide formyltransferase activity
GO:0005524 ATP binding
GO:0016742 hydroxymethyl-, formyl- and related transferase activity
GO:0016874 ligase activity
GO:0043815 phosphoribosylglycinamide formyltransferase 2 activity
GO:0046872 metal ion binding
Biological Process
GO:0006164 purine nucleotide biosynthetic process
GO:0006189 'de novo' IMP biosynthetic process
GO:0009152 purine ribonucleotide biosynthetic process
Cellular Component
GO:0005829 cytosol

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Cellular Component
External links
PDB RCSB:2dwc, PDBe:2dwc, PDBj:2dwc
PDBsum2dwc
PubMed
UniProtO58056|PURT_PYRHO Formate-dependent phosphoribosylglycinamide formyltransferase (Gene Name=purT)

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