Structure of PDB 2dfv Chain B

Receptor sequence
>2dfvB (length=346) Species: 70601 (Pyrococcus horikoshii OT3) [Search protein sequence]
EKMVAIMKTKPGYGAELVEVDVPKPGPGEVLIKVLATSICGTDLHIYEWN
EWAQSRIKPPQIMGHEVAGEVVEIGPGVEGIEVGDYVSVETHIVCGKCYA
CRRGQYHVCQNTKIFGVDTDGVFAEYAVVPAQNIWKNPKSIPPEYATLQE
PLGNAVDTVLAGPISGKSVLITGAGPLGLLGIAVAKASGAYPVIVSEPSD
FRRELAKKVGADYVINPFEEDVVKEVMDITDGNGVDVFLEFSGAPKALEQ
GLQAVTPAGRVSLLGLYPGKVTIDFNNLIIFKALTIYGITGRHLWETWYT
VSRLLQSGKLNLDPIITHKYKGFDKYEEAFELMRAGKTGKVVFMLK
3D structure
PDB2dfv The first crystal structure of L-threonine dehydrogenase.
ChainB
Resolution2.05 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) C42 G43 T44 H47 H67 E68 C97 C100 C103 C111 K115 P153 A157 K342
Catalytic site (residue number reindexed from 1) C40 G41 T42 H45 H65 E66 C95 C98 C101 C109 K113 P151 A155 K340
Enzyme Commision number 1.1.1.103: L-threonine 3-dehydrogenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN B C100 C103 C111 C98 C101 C109
BS02 NAD B N156 G175 G177 P178 L179 S198 E199 P200 R204 F243 S244 A246 L266 G267 L268 I291 T292 N154 G173 G175 P176 L177 S196 E197 P198 R202 F241 S242 A244 L264 G265 L266 I289 T290
Gene Ontology
Molecular Function
GO:0008270 zinc ion binding
GO:0008743 L-threonine 3-dehydrogenase activity
GO:0016491 oxidoreductase activity
GO:0016597 amino acid binding
GO:0030554 adenyl nucleotide binding
GO:0043168 anion binding
GO:0046872 metal ion binding
GO:0070401 NADP+ binding
GO:0070403 NAD+ binding
Biological Process
GO:0006566 threonine metabolic process
GO:0006567 threonine catabolic process
GO:0019518 L-threonine catabolic process to glycine
GO:0051262 protein tetramerization
GO:0051289 protein homotetramerization
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2dfv, PDBe:2dfv, PDBj:2dfv
PDBsum2dfv
PubMed17188300
UniProtO58389|TDH_PYRHO L-threonine 3-dehydrogenase (Gene Name=tdh)

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