Structure of PDB 2d4v Chain B

Receptor sequence
>2d4vB (length=427) Species: 930 (Acidithiobacillus thiooxidans) [Search protein sequence]
THIQKPATGSPLTLLNGVLQVPDQPIIPFIEGDGIGCDVTPAMRSVVDAA
VAKVYGGQRQIAWMELFAGQKAVQLYGEGQYLPDETMAAIREYKVAIKGP
LETPVGGGIRSLNVAMRQDLDLYVCLRPVRYFEGTPSPMRHPEKVDMVIF
RENSEDIYAGIEWPAGSPEAEKIIRFLREEMGVTKIRFPDSSAIGIKPVS
TEGSERLIRRTIQYALEHGKPSVSLVHKGNIMKFTEGGFRDWGYALAERE
FAGRVFTWRQKAAISKAEGKAAGQKAEQQAIADGKLIIKDVIADNFLQQI
LLRPEDYSVVATLNLNGDYVSDALAAEVGGIGMAPGANLSDTHAIFEATH
GTAPDIAGQGKANPSSLILSAVMMLEHLGWGEAAQAIVAAMNATIAAGEV
TGDLAALRGDVPALSTTEFTAALIRRF
3D structure
PDB2d4v Structure and quantum chemical analysis of NAD+-dependent isocitrate dehydrogenase: hydride transfer and co-factor specificity
ChainB
Resolution1.9 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Y160 K230 D296 D320 D324
Catalytic site (residue number reindexed from 1) Y158 K228 D294 D318 D322
Enzyme Commision number 1.1.1.42: isocitrate dehydrogenase (NADP(+)).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAD B N232 I294 N297 N230 I292 N295
BS02 FLC B S113 N115 R119 R129 R153 Y160 D320 S111 N113 R117 R127 R151 Y158 D318
BS03 NAD B I37 P102 L103 T105 N115 I333 E349 H352 G353 T354 A355 D357 A364 N365 D405 I35 P100 L101 T103 N113 I331 E347 H350 G351 T352 A353 D355 A362 N363 D403
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0000287 magnesium ion binding
GO:0004450 isocitrate dehydrogenase (NADP+) activity
GO:0016491 oxidoreductase activity
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0046872 metal ion binding
GO:0051287 NAD binding
Biological Process
GO:0006097 glyoxylate cycle
GO:0006099 tricarboxylic acid cycle

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Molecular Function
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Biological Process
External links
PDB RCSB:2d4v, PDBe:2d4v, PDBj:2d4v
PDBsum2d4v
PubMed17634983
UniProtQ8GAX0

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