Structure of PDB 2d1k Chain B

Receptor sequence
>2d1kB (length=260) Species: 9913 (Bos taurus) [Search protein sequence]
LKIAAFNIRTFGETKMSNATLASYIVRIVRRYDIVLIQEVRDSHLVAVGK
LLDYLNQDDPNTYHYVVSEPLGRNSYKERYLFLFRPNKVSVLDTYQYDDG
CESCGNDSFSREPAVVKFSSHSTKVKEFAIVALHSAPSDAVAEINSLYDV
YLDVQQKWHLNDVMLMGDFNADCSYVTSSQWSSIRLRTSSTFQWLIPDSA
DTTATSTNCAYDRIVVAGSLLQSSVVPGSAAPFDFQAAYGLSNEMALAIS
DHYPVEVTLT
3D structure
PDB2d1k Structural basis for the actin-binding function of missing-in-metastasis
ChainB
Resolution2.5 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) E39 Y76 E78 H134 D168 D212 H252
Catalytic site (residue number reindexed from 1) E39 Y76 E78 H134 D168 D212 H252
Enzyme Commision number 3.1.21.1: deoxyribonuclease I.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B S43 H44 S43 H44
BS02 CA B D201 T203 T205 T207 D201 T203 T205 T207
BS03 MG B D172 D198 D172 D198
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003779 actin binding
GO:0003824 catalytic activity
GO:0004519 endonuclease activity
GO:0004530 deoxyribonuclease I activity
GO:0004536 DNA nuclease activity
GO:0005515 protein binding
Biological Process
GO:0002283 neutrophil activation involved in immune response
GO:0002673 regulation of acute inflammatory response
GO:0006308 DNA catabolic process
GO:0006915 apoptotic process
GO:0070948 regulation of neutrophil mediated cytotoxicity
Cellular Component
GO:0005576 extracellular region
GO:0005634 nucleus
GO:0005635 nuclear envelope
GO:0031410 cytoplasmic vesicle
GO:0042588 zymogen granule

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2d1k, PDBe:2d1k, PDBj:2d1k
PDBsum2d1k
PubMed17292833
UniProtP00639|DNAS1_BOVIN Deoxyribonuclease-1 (Gene Name=DNASE1)

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