Structure of PDB 2cze Chain B

Receptor sequence
>2czeB (length=208) Species: 70601 (Pyrococcus horikoshii OT3) [Search protein sequence]
MIVLALDVYEGERAIKIAKSVKDYISMIKVNWPLILGSGVDIIRRLKEET
GVEIIADLKLADIPNTNRLIARKVFGAGADYVIVHTFVGRDSVMAVKELG
EIIMVVEMSHPGALEFINPLTDRFIEVANEIEPFGVIAPGTRPERIGYIR
DRLKEGIKILAPGIGAQGGKAKDAVKAGADYIIVGRAIYNAPNPREAAKA
IYDEIRGV
3D structure
PDB2cze Crystal structure of orotidine 5'-phosphate decarboxylase from Pyrococcus horikoshii OT3 complexed with UMP
ChainB
Resolution1.85 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) K29 D57 K59 D62
Catalytic site (residue number reindexed from 1) K29 D57 K59 D62
Enzyme Commision number 4.1.1.23: orotidine-5'-phosphate decarboxylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 U5P B D62 I63 T66 D62 I63 T66
BS02 U5P B D7 K29 N31 K59 M108 S109 P162 Q167 G185 R186 D7 K29 N31 K59 M108 S109 P162 Q167 G185 R186
Gene Ontology
Molecular Function
GO:0004590 orotidine-5'-phosphate decarboxylase activity
GO:0016831 carboxy-lyase activity
Biological Process
GO:0006207 'de novo' pyrimidine nucleobase biosynthetic process
GO:0006221 pyrimidine nucleotide biosynthetic process
GO:0044205 'de novo' UMP biosynthetic process
Cellular Component
GO:0005829 cytosol

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Cellular Component
External links
PDB RCSB:2cze, PDBe:2cze, PDBj:2cze
PDBsum2cze
PubMed
UniProtO58462|PYRF_PYRHO Orotidine 5'-phosphate decarboxylase (Gene Name=pyrF)

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