Structure of PDB 2chn Chain B

Receptor sequence
>2chnB (length=639) Species: 226186 (Bacteroides thetaiotaomicron VPI-5482) [Search protein sequence]
LQPPPQQLIVQNKTIDLPAVYQLNGGEEANPHAVKVLKELLGMLISIGEK
GDKSVRKYSRQIPDHKEGYYLSVNEKEIVLAGNDERGTYYALQTFAQLLK
DGKLPEVEIKDYPSVRYRGVVEGFYGTPWSHQARLSQLKFYGKNKMNTYI
YGPKDDPYHSAPNWRLPYPDKEAAQLQELVAVANENEVDFVWAIHPGQDI
KWNKEDRDLLLAKFEKMYQLGVRSFAVFFDDISGEGTNPQKQAELLNYID
EKFAQVKPDINQLVMCPTEYNKSWSNPNGNYLTTLGDKLNPSIQIMWTGD
RVISDITRDGISWINERIKRPAYIWWNFPVSDYVRDHLLLGPVYGNDTTI
AKEMSGFVTNPMEHAESSKIAIYSVASYAWNPAKYDTWQTWKDAIRTILP
SAAEELECFAMHNSDLGPNGHGYRREESMDIQPAAERFLKAFKEGKNYDK
ADFETLQYTFERMKESADILLMNTENKPLIVEITPWVHQFKLTAEMGEEV
LKMVEGRNESYFLRKYNHVKALQQQMFYIDQTSNQNPYQPGVKTATRVIK
PLIDRTFATVVKFFNQKFNAHLDATTDYMPHKMNLPLQVKANRVLISPVE
IELDAIYPGENIQINFRLSAGLQKAPVKFVRFFVLTIEK
3D structure
PDB2chn Structure and Mechanism of a Bacterial B-Glucosaminidase Having O-Glcnacase Activity
ChainB
Resolution1.95 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.2.1.169: protein O-GlcNAcase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B S681 F691 V692 R693 F694 S619 F629 V630 R631 F632
BS02 CA B E32 E61 D64 E28 E49 D52
BS03 NGT B G135 K166 D242 Y282 W337 N339 D344 G123 K154 D230 Y270 W325 N327 D332 MOAD: Ki=0.2uM
Gene Ontology
Molecular Function
GO:0015929 hexosaminidase activity
GO:0016231 beta-N-acetylglucosaminidase activity
GO:0016798 hydrolase activity, acting on glycosyl bonds
GO:0042802 identical protein binding
GO:0102571 [protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine/L-threonine O-N-acetyl-alpha-D-glucosaminase activity
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006517 protein deglycosylation
GO:1901135 carbohydrate derivative metabolic process

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:2chn, PDBe:2chn, PDBj:2chn
PDBsum2chn
PubMed16565725
UniProtQ89ZI2|OGA_BACTN O-GlcNAcase BT_4395 (Gene Name=BT_4395)

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