Structure of PDB 2ch6 Chain B

Receptor sequence
>2ch6B (length=310) Species: 9606 (Homo sapiens) [Search protein sequence]
GGVEGGGTRSEVLADGLSTNHIGTDKCVERINEMGVDPLVPLRSLGLSLS
GGEDAGRILIEELRDRFPYLSESYLITTDAAGSIATATPDGGVVLISGTG
SNCRLINPDGSESGCGGWGHMMGDEGSAYWIAHQAVKIVFDSIDNLEAAP
HDIGYVKQAMFHYFQVPDRLGILTHLYRDFDKCRFAGFCRKIAEGAQQGD
PLSRYIFRKAGEMLGRHIVAVLPEIDPVLFQGKIGLPILCVGSVWKSWEL
LKEGFLLALTQGREIQAQNFFSSFTLMKLRHSSALGGASLGARHMDYSAN
AIAFYSYTFS
3D structure
PDB2ch6 Structures of Human N-Acetylglucosamine Kinase in Two Complexes with N-Acetylglucosamine and with Adp/Glucose: Insights Into Substrate Specificity and Regulation.
ChainB
Resolution2.72 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.1.-
2.7.1.59: N-acetylglucosamine kinase.
2.7.1.60: N-acylmannosamine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP B G11 G12 T13 T127 A214 C217 R218 S271 K274 S275 G6 G7 T8 T99 A186 C189 R190 S243 K246 S247
BS02 GLC B S76 G77 D107 I124 S129 N130 G145 G147 D152 S50 G51 D79 I96 S101 N102 G117 G119 D124
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0045127 N-acetylglucosamine kinase activity
GO:0160047 muramyl dipeptide kinase activity
Biological Process
GO:0006044 N-acetylglucosamine metabolic process
GO:0006046 N-acetylglucosamine catabolic process
GO:0006048 UDP-N-acetylglucosamine biosynthetic process
GO:0006051 N-acetylmannosamine metabolic process
GO:0016310 phosphorylation
GO:0019262 N-acetylneuraminate catabolic process
GO:0032495 response to muramyl dipeptide
GO:0042742 defense response to bacterium
GO:0045087 innate immune response
GO:0046835 carbohydrate phosphorylation
GO:0070434 positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway
Cellular Component
GO:0005829 cytosol
GO:0070062 extracellular exosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2ch6, PDBe:2ch6, PDBj:2ch6
PDBsum2ch6
PubMed17010375
UniProtQ9UJ70|NAGK_HUMAN N-acetyl-D-glucosamine kinase (Gene Name=NAGK)

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