Structure of PDB 2ccg Chain B

Receptor sequence
>2ccgB (length=199) Species: 1280 (Staphylococcus aureus) [Search protein sequence]
MSAFITFEGPEGSGKTTVINEVYHRLVKDYDVIMTREPGGVPTGEEIRKI
VLEGNDMDIRTEAMLFAASRREHLVLKVIPALKEGKVVLCDRYIDSSLAY
QGYARGIGVEEVRALNEFAINGLYPDLTIYLNVSAEVGRERIIKNSLDQE
DLKFHEKVIEGYQEIIHNESQRFKSVNADQPLENVVEDTYQTIIKYLEK
3D structure
PDB2ccg Structures of S. Aureus Thymidylate Kinase Reveal an Atypical Active Site Configuration and an Intermediate Conformational State Upon Substrate Binding
ChainB
Resolution2.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.4.9: dTMP kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 TMP B E203 K204 E198 K199
BS02 TMP B E11 R36 F66 R70 R92 S96 S97 Y100 Q101 E11 R36 F66 R70 R92 S96 S97 Y100 Q101
Gene Ontology
Molecular Function
GO:0004798 thymidylate kinase activity
GO:0005524 ATP binding
GO:0016301 kinase activity
Biological Process
GO:0006227 dUDP biosynthetic process
GO:0006233 dTDP biosynthetic process
GO:0006235 dTTP biosynthetic process
GO:0009165 nucleotide biosynthetic process
GO:0016310 phosphorylation
GO:0046940 nucleoside monophosphate phosphorylation
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2ccg, PDBe:2ccg, PDBj:2ccg
PDBsum2ccg
PubMed16522804
UniProtP65248|KTHY_STAAM Thymidylate kinase (Gene Name=tmk)

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