Structure of PDB 2c95 Chain B

Receptor sequence
>2c95B (length=194) Species: 9606 (Homo sapiens) [Search protein sequence]
EEKLKKTNIIFVVGGPGSGKGTQCEKIVQKYGYTHLSTGDLLRSEVSSGS
ARGKKLSEIMEKGQLVPLETVLDMLRDAMVAKVNTSKGFLIDGYPREVQQ
GEEFERRIGQPTLLLYVDAGPETMTQRLLKRGETSGRVDDNEETIKKRLE
TYYKATEPVIAFYEKRGIVRKVNAEGSVDSVFSQVCTHLDALLN
3D structure
PDB2c95 Structure of Adenylate Kinase 1 in Complex with P1, P4-Di(Adenosine)Tetraphosphate
ChainB
Resolution1.71 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) K21 R97 R132 R138 R149
Catalytic site (residue number reindexed from 1) K20 R96 R131 R137 R148
Enzyme Commision number 2.7.4.10: nucleoside-triphosphate--adenylate kinase.
2.7.4.3: adenylate kinase.
2.7.4.6: nucleoside-diphosphate kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 B4P B G18 G20 K21 G22 T23 T39 L43 R44 M61 Q65 L66 V67 G94 R97 Q101 R128 R132 R138 R149 V179 G17 G19 K20 G21 T22 T38 L42 R43 M60 Q64 L65 V66 G93 R96 Q100 R127 R131 R137 R148 V178
Gene Ontology
Molecular Function
GO:0004017 adenylate kinase activity
GO:0004550 nucleoside diphosphate kinase activity
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0019205 nucleobase-containing compound kinase activity
GO:0047506 (deoxy)adenylate kinase activity
Biological Process
GO:0006139 nucleobase-containing compound metabolic process
GO:0006172 ADP biosynthetic process
GO:0009142 nucleoside triphosphate biosynthetic process
GO:0015949 nucleobase-containing small molecule interconversion
GO:0016310 phosphorylation
GO:0046033 AMP metabolic process
GO:0046034 ATP metabolic process
GO:0046940 nucleoside monophosphate phosphorylation
Cellular Component
GO:0001520 outer dense fiber
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0036126 sperm flagellum
GO:0070062 extracellular exosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2c95, PDBe:2c95, PDBj:2c95
PDBsum2c95
PubMed
UniProtP00568|KAD1_HUMAN Adenylate kinase isoenzyme 1 (Gene Name=AK1)

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