Structure of PDB 2c7v Chain B

Receptor sequence
>2c7vB (length=254) Species: 5702 (Trypanosoma brucei brucei) [Search protein sequence]
EAPAAVVTGAAKRIGRAIAVKLHQTGYRVVIHYHNSAEAAVSLADELNKE
RSNTAVVCQADLTNSNVLPASCEEIINSCFRAFGRCDVLVNNASAFYPTP
LVQNGKTVETQVAELIGTNAIAPFLLTMSFAQRQKTSSNLSIVNLCDAMV
DQPCMAFSLYNMGKHALVGLTQSAALELAPYGIRVNGVAPGVSLLPVAMG
EEEKDKWRRKVPLGRREASAEQIADAVIFLVSGSAQYITGSIIKVDGGLS
LVHA
3D structure
PDB2c7v Structure and Reactivity of Trypanosoma Brucei Pteridine Reductase: Inhibition by the Archetypal Antifolate Methotrexate
ChainB
Resolution2.2 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) R14 D161 Y174 K178
Catalytic site (residue number reindexed from 1) R13 D147 Y160 K164
Enzyme Commision number 1.5.1.33: pteridine reductase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAP B R14 I15 Y34 H35 N36 S37 D62 L63 N93 S95 T126 L159 C160 K178 P204 G205 S207 R13 I14 Y33 H34 N35 S36 D61 L62 N92 S94 T118 L145 C146 K164 P190 G191 S193
BS02 MTX B R14 S95 F97 P99 X168 Y174 L208 P210 M213 W221 R13 S94 F96 P98 X154 Y160 L194 P196 M199 W207 MOAD: Ki=152nM
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0016491 oxidoreductase activity
GO:0047040 pteridine reductase activity

View graph for
Molecular Function
External links
PDB RCSB:2c7v, PDBe:2c7v, PDBj:2c7v
PDBsum2c7v
PubMed16968221
UniProtO76290

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