Structure of PDB 2c6w Chain B

Receptor sequence
>2c6wB (length=384) Species: 171101 (Streptococcus pneumoniae R6) [Search protein sequence]
NYPAYMDNYLKEVINQVEEETGYNLLTTGMDVYTNVDQEAQKHLWDIYNT
DEYVAYPDDELQVASTIVDVSNGKVIAQLGARHQSSNVSFGINQAVETNR
DWGSTMKPITDYAPALEYGVYDSTATIVHDEPYNYPGTNTPVYNWDRGYF
GNITLQYALQQSRNVPAVETLNKVGLNRAKTFLNGLGIDYPSIHYSNAIS
SNTTESDKKYGASSEKMAAAYAAFANGGTYYKPMYIHKVVFSDGSEKEFS
NVGTRAMKETTAYMMTDMMKTVLTYGTGRNAYLAWLPQAGKTGTSNYTDE
EIENHIKTSQFVAPDELFAGYTRKYSMAVWTGYSNRLTPLVGNGLTVAAK
VYRSMMTYLSEGSNPEDWNIPEGLYRNGEFVFKN
3D structure
PDB2c6w Crystal Structure of Penicillin-Binding Protein 1A (Pbp1A) Reveals a Mutational Hotspot Implicated in Beta-Lactam Resistance in Streptococcus Pneumoniae.
ChainB
Resolution2.61 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.4.99.28: peptidoglycan glycosyltransferase.
3.4.16.4: serine-type D-Ala-D-Ala carboxypeptidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B N267 Y268 L291 G295 M296 D297 V298 Y299 T300 V302 Q304 N1 Y2 L25 G29 M30 D31 V32 Y33 T34 V36 Q38
BS02 ZN B H395 E435 H129 E169
Gene Ontology
Molecular Function
GO:0008658 penicillin binding

View graph for
Molecular Function
External links
PDB RCSB:2c6w, PDBe:2c6w, PDBj:2c6w
PDBsum2c6w
PubMed16316661
UniProtQ8DR59|PBPA_STRR6 Penicillin-binding protein 1A (Gene Name=pbpA)

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