Structure of PDB 2c49 Chain B

Receptor sequence
>2c49B (length=298) Species: 2190 (Methanocaldococcus jannaschii) [Search protein sequence]
GKMEKITCVGHTALDYIFNVEKFPEPNTSIQIPSARKYYGGAAANTAVGI
KKLGVNSELLSCVGYDFKNSGYERYLKNLDINISKLYYSEEEETPKAWIF
TDKDNNQITFFLWGAAKHYKELNPPNFNTEIVHIATGDPEFNLKCAKKAY
GNNLVSFDPGQDLPQYSKEMLLEIIEHTNFLFMNKHEFERASNLLNFEID
DYLERVDALIVTKGSKGSVIYTKDKKIEIPCIKAGKVIDPTGAGDSYRAG
FLSAYVKGYDLEKCGLIGAATASFVVEAKGCQTNLPTWDKVVERLEKH
3D structure
PDB2c49 Structure of Methanocaldococcus Jannaschii Nucleoside Kinase: An Archaeal Member of the Ribokinase Family.
ChainB
Resolution1.92 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) G244 A245 G246 D247
Catalytic site (residue number reindexed from 1) G242 A243 G244 D245
Enzyme Commision number 2.7.1.213: cytidine kinase.
2.7.1.73: inosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADN B H13 D17 G42 G43 H11 D15 G40 G41
BS02 ANP B N186 T214 K215 G216 C233 I234 T243 A245 G246 Y249 A274 N184 T212 K213 G214 C231 I232 T241 A243 G244 Y247 A272
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0005524 ATP binding
GO:0008906 inosine kinase activity
GO:0016301 kinase activity
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0019206 nucleoside kinase activity
GO:0043771 cytidine kinase activity
GO:0106366 guanosine kinase activity
Biological Process
GO:0009165 nucleotide biosynthetic process
GO:0009224 CMP biosynthetic process
GO:0016310 phosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:2c49, PDBe:2c49, PDBj:2c49
PDBsum2c49
PubMed16929110
UniProtQ57849|NK_METJA Nucleoside kinase (Gene Name=MJ0406)

[Back to BioLiP]