Structure of PDB 2c2k Chain B

Receptor sequence
>2c2kB (length=103) Species: 9606 (Homo sapiens) [Search protein sequence]
ASGVDDDMACHKIPVEADFLYAYSTAPGYYSWRNSKDGSWFIQSLCAMLK
QYADKLEFMHILTRVNRKVATEFESFSFDATFHAKKQIPCIVSMLTKELY
FYH
3D structure
PDB2c2k Design, Synthesis, and Evaluation of Aza-Peptide Michael Acceptors as Selective and Potent Inhibitors of Caspases-2, -3, -6, -7, -8, -9, and - 10.
ChainB
Resolution1.87 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.22.56: caspase-3.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B Y204 S205 W206 R207 S209 S249 Y30 S31 W32 R33 S35 S75
Gene Ontology
Molecular Function
GO:0004197 cysteine-type endopeptidase activity
GO:0008234 cysteine-type peptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:2c2k, PDBe:2c2k, PDBj:2c2k
PDBsum2c2k
PubMed16970398
UniProtP42574|CASP3_HUMAN Caspase-3 (Gene Name=CASP3)

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