Structure of PDB 2c19 Chain B

Receptor sequence
>2c19B (length=328) Species: 287 (Pseudomonas aeruginosa) [Search protein sequence]
FTPANRAYPYTRLRRNRRDDFSRRLVRENVLTVDDLILPVFVLDGVNQRE
SIPSMPGVERLSIDQLLIEAEEWVALGIPALALFPVTPVEKKSLDAAEAY
NPEGIAQRATRALRERFPELGIITDVALDPFTTHGQDGILDDDGYVLNDV
SIDVLVRQALSHAEAGAQVVAPSDMMDGRIGAIREALESAGHTNVRVMAY
SAKYASAYYGPFRDAVGSAGNKATYQMDPANSDEALHEVAADLAEGADMV
MVKPGMPYLDIVRRVKDEFRAPTFVYQVSGEYAMHMGAIQNGWLAESVIL
ESLTAFKRAGADGILTYFAKQAAEQLRR
3D structure
PDB2c19 Probing the Active Site of Pseudomonas Aeruginosa Porphobilinogen Synthase Using Newly Developed Inhibitors.
ChainB
Resolution2.05 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) K205 K260
Catalytic site (residue number reindexed from 1) K203 K253
Enzyme Commision number 4.2.1.24: porphobilinogen synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG B Q332 R335 Q325 R328
Gene Ontology
Molecular Function
GO:0004655 porphobilinogen synthase activity
GO:0008270 zinc ion binding
GO:0016829 lyase activity
GO:0046872 metal ion binding
Biological Process
GO:0006779 porphyrin-containing compound biosynthetic process
GO:0006782 protoporphyrinogen IX biosynthetic process
GO:0006783 heme biosynthetic process
GO:0033014 tetrapyrrole biosynthetic process
Cellular Component
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2c19, PDBe:2c19, PDBj:2c19
PDBsum2c19
PubMed16819823
UniProtQ59643|HEM2_PSEAE Delta-aminolevulinic acid dehydratase (Gene Name=hemB)

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