Structure of PDB 2bt4 Chain B

Receptor sequence
>2bt4B (length=149) Species: 1902 (Streptomyces coelicolor) [Search protein sequence]
RSLANAPIMILNGPNLNLLGQRQPEIYGSDTLADVEALCVKAAAAHGGTV
DFRQSNHEGELVDWIHEARLNHCGIVINPAAYSHTSVAILDALNTCDGLP
VVEVHISNIHQREPFRHHSYVSQRADGVVAGCGVQGYVFGVERIAALAG
3D structure
PDB2bt4 Rational Design of New Bifunctional Inhibitors of Type II Dehydroquinase.
ChainB
Resolution1.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 4.2.1.10: 3-dehydroquinate dehydratase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA2 B N216 L217 L219 L220 R223 Y228 N279 A281 A282 H285 H306 I307 S308 R317 N15 L16 L18 L19 R22 Y27 N78 A80 A81 H84 H105 I106 S107 R116 MOAD: Ki=33uM
Gene Ontology
Molecular Function
GO:0003855 3-dehydroquinate dehydratase activity
GO:0016829 lyase activity
Biological Process
GO:0008652 amino acid biosynthetic process
GO:0009073 aromatic amino acid family biosynthetic process
GO:0009423 chorismate biosynthetic process
GO:0019631 quinate catabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:2bt4, PDBe:2bt4, PDBj:2bt4
PDBsum2bt4
PubMed16106291
UniProtP15474|AROQ_STRCO 3-dehydroquinate dehydratase (Gene Name=aroQ)

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