Structure of PDB 2bbt Chain B

Receptor sequence
>2bbtB (length=258) Species: 9606 (Homo sapiens) [Search protein sequence]
TTEVVMENVTAFWEEGFGELFEKAKQNNNNTPVLKDINFKIERGQLLAVA
GSTGAGKTSLLMMIMGELEPSEGKIKHSGRISFCSQNSWIMPGTIKENII
GVSYDEYRYRSVIKACQLEEDISKFAEKDNIVLGITLSGGQRARISLARA
VYKDADLYLLDSPFGYLDVLTEKEIFESCVCKLMANKTRILVTSKMEHLK
KADKILILHEGSSYFYGTFSELQNLRPDFSSKLMDSFDQFSAERRNSILT
ETLHRFSL
3D structure
PDB2bbt Structure and dynamics of NBD1 from CFTR characterized using crystallography and hydrogen/deuterium exchange mass spectrometry.
ChainB
Resolution2.3 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 5.6.1.6: channel-conductance-controlling ATPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG B T465 Q493 T58 Q86
BS02 ATP B W401 V440 T460 G461 G463 K464 T465 S466 W13 V33 T53 G54 G56 K57 T58 S59
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity

View graph for
Molecular Function
External links
PDB RCSB:2bbt, PDBe:2bbt, PDBj:2bbt
PDBsum2bbt
PubMed19944699
UniProtP13569|CFTR_HUMAN Cystic fibrosis transmembrane conductance regulator (Gene Name=CFTR)

[Back to BioLiP]