Structure of PDB 2b92 Chain B

Receptor sequence
>2b92B (length=290) Species: 9606 (Homo sapiens) [Search protein sequence]
HMTGPMCLIENTNGRLMANPEALKILSAITQPMVVVAIVGLYRTGKSYLM
NKLAGKKKGFSLGSTVQSHTKGIWMWCVPHPKKPGHILVLLDTEGLGDVE
KGDNQNDSWIFALAVLLSSTFVYNSIGTINQQAMDQLYYVTELTHRIRSK
SSFVSFFPDFVWTLRDFSLDLEADGQPLTPDEYLTYSLKLKKGTSQKDET
FNLPRLCIRKFFPKKKCFVFDRPVHRRKLAQLEKLQDEELDPEFVQQVAD
FCSYIFSNSKTKTLSGGIQVNGPRLESLVLTYVNAISSGD
3D structure
PDB2b92 How guanylate-binding proteins achieve assembly-stimulated processive cleavage of GTP to GMP.
ChainB
Resolution3.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.1.-
3.6.5.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG B S52 T75 S47 T70
BS02 GDP B R48 T49 G50 K51 S52 Y53 L67 G68 R183 D184 R240 P241 L247 L250 R43 T44 G45 K46 S47 Y48 L62 G63 R165 D166 R222 P223 L229 L232
BS03 AF3 B R48 K51 S73 H74 T75 G100 R43 K46 S68 H69 T70 G95
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding

View graph for
Molecular Function
External links
PDB RCSB:2b92, PDBe:2b92, PDBj:2b92
PDBsum2b92
PubMed16511497
UniProtP32455|GBP1_HUMAN Guanylate-binding protein 1 (Gene Name=GBP1)

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