Structure of PDB 2b8h Chain B

Receptor sequence
>2b8hB (length=388) Species: 11320 (Influenza A virus) [Search protein sequence]
REFNNLTKGLCTINSWHIYGKDNAVRIGEDSDVLVTREPYVSCDPDECRF
YALSQGTTIRGKHSNGTIHDRSQYRDLISWPLSSPPTVYNSRVECIGWSS
TSCHDGRARMSICISGPNNNASAVIWYNRRPVTEINTWARNILRTQESEC
VCQNGVCPVVFTDGSATGPAETRIYYFKEGKILKWEPLTGTAKHIEECSC
YGEQAGVTCTCRDNWQGSNRPVIQIDPVAMTHTSQYICSPVLTDNPRPND
PTVGKCNDPYPGNNNNGVKGFSYLDGGNTWLGRTISVASRSGYEMLKVPN
ALTDDRSKPTQGQTIVLNTDWSGYSGSFMDYWAEGECYRACFYVELIRGR
PKEDKVWWTSNSIVSMCSSTEFLGQWNWPDGAKIEYFL
3D structure
PDB2b8h Structure of a calcium-deficient form of influenza virus neuraminidase: implications for substrate binding.
ChainB
Resolution2.2 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) D151 E278 R293 R371 Y405
Catalytic site (residue number reindexed from 1) D70 E197 R212 R290 Y324
Enzyme Commision number 3.2.1.18: exo-alpha-sialidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MAN B D331 K389 D250 K308
BS02 MAN B N330 R364 I366 V368 N249 R283 I285 V287
Gene Ontology
Molecular Function
GO:0004308 exo-alpha-sialidase activity
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0046761 viral budding from plasma membrane
Cellular Component
GO:0016020 membrane
GO:0033644 host cell membrane
GO:0055036 virion membrane

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:2b8h, PDBe:2b8h, PDBj:2b8h
PDBsum2b8h
PubMed16929094
UniProtP05803|NRAM_I84A1 Neuraminidase (Gene Name=NA)

[Back to BioLiP]