Structure of PDB 2b77 Chain B

Receptor sequence
>2b77B (length=112) Species: 9606 (Homo sapiens) [Search protein sequence]
CPLMVKVLDAVRGSPAINVAVHVFRKAADDTWEPFASGKTSESGELHGLT
TEEEFVEGIYKVEIDTKSYWKALGISPFHEHAEVVFTANDSGRYTIAALL
SPYSYSTTAVVT
3D structure
PDB2b77 Diflunisal analogues stabilize the native state of transthyretin. Potent inhibition of amyloidogenesis.
ChainB
Resolution1.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 3CA B K15 L110 K6 L99
Gene Ontology
Molecular Function
GO:0005179 hormone activity
GO:0005515 protein binding
GO:0042802 identical protein binding
GO:0070324 thyroid hormone binding
Biological Process
GO:0006144 purine nucleobase metabolic process
GO:0007165 signal transduction
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0035578 azurophil granule lumen
GO:0070062 extracellular exosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2b77, PDBe:2b77, PDBj:2b77
PDBsum2b77
PubMed14711308
UniProtP02766|TTHY_HUMAN Transthyretin (Gene Name=TTR)

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