Structure of PDB 2b4b Chain B

Receptor sequence
>2b4bB (length=170) Species: 9606 (Homo sapiens) [Search protein sequence]
AKFVIRPATAADCSDILRLIKELARYEYMEEQVILTEKDLLEDGFGEHPF
YHCLVAEVPKEHWTPEGHSIVGFAMYYFTYDPWIGKLLYLEDFFVMSDYR
GFGIGSEILKNLSQVAMRCRCSSMHFLVAEWNEPSINFYKRRGASDLSSE
EGWRLFKIDKEYLLKMATEE
3D structure
PDB2b4b Structures of wild-type and mutant human spermidine/spermine N1-acetyltransferase, a potential therapeutic drug target
ChainB
Resolution2.0 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 2.3.1.57: diamine N-acetyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 COA B Y27 F94 F95 V96 R101 G102 G104 I105 G106 S107 P135 S136 F139 R142 R143 Y26 F93 F94 V95 R100 G101 G103 I104 G105 S106 P134 S135 F138 R141 R142
BS02 B33 B D82 W84 I85 L148 E152 W154 D81 W83 I84 L147 E151 W153
Gene Ontology
Molecular Function
GO:0004145 diamine N-acetyltransferase activity
GO:0005515 protein binding
GO:0008080 N-acetyltransferase activity
GO:0016746 acyltransferase activity
GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups
GO:0019809 spermidine binding
GO:0042802 identical protein binding
Biological Process
GO:0001525 angiogenesis
GO:0006596 polyamine biosynthetic process
GO:0009447 putrescine catabolic process
GO:0032918 spermidine acetylation
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:2b4b, PDBe:2b4b, PDBj:2b4b
PDBsum2b4b
PubMed16455797
UniProtP21673|SAT1_HUMAN Diamine acetyltransferase 1 (Gene Name=SAT1)

[Back to BioLiP]