Structure of PDB 2b1z Chain B

Receptor sequence
>2b1zB (length=238) Species: 9606 (Homo sapiens) [Search protein sequence]
SLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADREL
VHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLF
APNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILL
NSGVYTFLKSLEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLL
ILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAH
3D structure
PDB2b1z Molecular characterization of a B-ring unsaturated estrogen: implications for conjugated equine estrogen components of premarin.
ChainB
Resolution1.78 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B I358 K362 L372 V376 E380 D538 L539 E542 I54 K58 L68 V72 E76 D229 L230 E233
BS02 17M B L346 E353 L387 F404 H524 L525 L42 E49 L83 F100 H215 L216 MOAD: ic50=79nM
External links
PDB RCSB:2b1z, PDBe:2b1z, PDBj:2b1z
PDBsum2b1z
PubMed17949766
UniProtP03372|ESR1_HUMAN Estrogen receptor (Gene Name=ESR1)

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