Structure of PDB 2b1v Chain B

Receptor sequence
>2b1vB (length=244) Species: 9606 (Homo sapiens) [Search protein sequence]
SLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADREL
VHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLF
APNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILL
NSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRL
AQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHL
3D structure
PDB2b1v Identification of ligands with bicyclic scaffolds provides insights into mechanisms of estrogen receptor subtype selectivity.
ChainB
Resolution1.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B I358 K362 L372 V376 E380 D538 L539 E542 I54 K58 L68 V72 E76 D234 L235 E238
BS02 458 B M343 L346 E353 L391 F404 M421 H524 M39 L42 E49 L87 F100 M117 H220 MOAD: Ki=1.8uM
External links
PDB RCSB:2b1v, PDBe:2b1v, PDBj:2b1v
PDBsum2b1v
PubMed16648639
UniProtP03372|ESR1_HUMAN Estrogen receptor (Gene Name=ESR1)

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