Structure of PDB 2awh Chain B

Receptor sequence
>2awhB (length=250) Species: 9606 (Homo sapiens) [Search protein sequence]
DLKAFSKHIYNAYLKNFNMTKKKARSILTAPFVIHDIETLWQAEKGLVWE
ISVHVFYRCQCTTVETVRELTEFAKSIPSFSSLFLNDQVTLLKYGVHEAI
FAMLASIVNKDGLLVANGSGFVTREFLRSLRKPFSDIIEPKFEFAVKFNA
LELDDSDLALFIAAIILCGDRPGLMNVPRVEAIQDTILRALEFHLQANHP
DAQQLFPKLLQKMADLRQLVTEHAQMMQRIKKTETETSLHPLLQEIYKDM
3D structure
PDB2awh Recombinant Human PPAR-beta/delta Ligand-binding Domain is Locked in an Activated Conformation by Endogenous Fatty Acids
ChainB
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 B7G B K319 E471 I472 K474 K93 E245 I246 K248
BS02 B7G B L311 N312 V315 L85 N86 V89
BS03 VCA B C285 T289 H323 F327 H449 Y473 C59 T63 H97 F101 H223 Y247
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2awh, PDBe:2awh, PDBj:2awh
PDBsum2awh
PubMed16405912
UniProtQ03181|PPARD_HUMAN Peroxisome proliferator-activated receptor delta (Gene Name=PPARD)

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