Structure of PDB 2aoa Chain B

Receptor sequence
>2aoaB (length=77) Species: 9606 (Homo sapiens) [Search protein sequence]
AKAEEMLSKQRHDGAFLIREGDFSLSVKFGNDVQHFKVLRDGAGKYFLWV
VKFNSLNELVDYHRSTSVSRNQQIFLR
3D structure
PDB2aoa Crystal Structures of a High-affinity Macrocyclic Peptide Mimetic in Complex with the Grb2 SH2 Domain.
ChainB
Resolution1.99 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 S1S B W121 V122 E130 W49 V50 E58
BS02 S1S B R86 S96 Q106 H107 F108 K109 L111 L120 W121 R19 S24 Q34 H35 F36 K37 L39 L48 W49
External links
PDB RCSB:2aoa, PDBe:2aoa, PDBj:2aoa
PDBsum2aoa
PubMed16165154
UniProtP62993|GRB2_HUMAN Growth factor receptor-bound protein 2 (Gene Name=GRB2)

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