Structure of PDB 2ao2 Chain B

Receptor sequence
>2ao2B (length=165) Species: 83332 (Mycobacterium tuberculosis H37Rv) [Search protein sequence]
GTSQLAELVDAAAERLEVADPVAAFKWRAQLPIEDSGRVEQQLAKLGEDA
RSQHIDPDYVTRVFDDQIRATEAIEYSRFSDWKLNPASAPPEPPDLSASR
SAIDSLNNRMLSQIWSHWSLLSAPSCAAQLDRAKRDIVRSRHLDSLYQRA
LTTATQSYCQALPPA
3D structure
PDB2ao2 The 2.15 A crystal structure of Mycobacterium tuberculosis chorismate mutase reveals an unexpected gene duplication and suggests a role in host-pathogen interactions.
ChainB
Resolution2.07 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) R49 K60 D69 T105 E106 E109 R134
Catalytic site (residue number reindexed from 1) R15 K26 D35 T71 E72 E75 R100
Enzyme Commision number 5.4.99.5: chorismate mutase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SO4 B K60 R72 Q76 K26 R38 Q42
BS02 TRP B L65 P66 I67 E68 L31 P32 I33 E34
Gene Ontology
Molecular Function
GO:0004106 chorismate mutase activity
GO:0005515 protein binding
GO:0016853 isomerase activity
Biological Process
GO:0009697 salicylic acid biosynthetic process
GO:0046417 chorismate metabolic process
Cellular Component
GO:0005576 extracellular region

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2ao2, PDBe:2ao2, PDBj:2ao2
PDBsum2ao2
PubMed16752890
UniProtP9WIB9|SCMU_MYCTU Secreted chorismate mutase (Gene Name=Rv1885c)

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