Structure of PDB 2al1 Chain B

Receptor sequence
>2al1B (length=431) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]
AVSKVYARSVYDSRGNPTVEVELTTEKGVFRSIVPSGASTGVHEALEMRD
GDKSKWMGKGVLHAVKNVNDVIAPAFVKANIDVKDQKAVDDFLISLDGTA
NKSKLGANAILGVSLAASRAAAAEKNVPLYKHLADLSKSKTSPYVLPVPF
LNVLNGGALALQEFMIAPTGAKTFAEALRIGSEVYHNLKSLTKKRYGASA
GNVGDEGGVAPNIQTAEEALDLIVDAIKAAGHDGKVKIGLDCASSEFFKD
GKYDLDFKNPNSDKSKWLTGPQLADLYHSLMKRYPIVSIEDPFAEDDWEA
WSHFFKTAGIQIVADDLTVTNPKRIATAIEKKAADALLLKVNQIGTLSES
IKAAQDSFAAGWGVMVSHRSGETEDTFIADLVVGLRTGQIKTGAPARSER
LAKLNQLLRIEEELGDNAVFAGENFHHGDKL
3D structure
PDB2al1 Structure and catalytic properties of an engineered heterodimer of enolase composed of one active and one inactive subunit
ChainB
Resolution1.5 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) S39 E168 E211 D246 E295 D320 K345 H373 K396
Catalytic site (residue number reindexed from 1) S39 E163 E206 D241 E290 D315 K340 H368 K391
Enzyme Commision number 4.2.1.11: phosphopyruvate hydratase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG B D246 E295 D320 D241 E290 D315
BS02 PEP B G37 A38 S39 E168 D246 D320 K345 R374 S375 K396 G37 A38 S39 E163 D241 D315 K340 R369 S370 K391
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0004634 phosphopyruvate hydratase activity
GO:0016829 lyase activity
GO:0046872 metal ion binding
GO:1904408 melatonin binding
Biological Process
GO:0006096 glycolytic process
GO:0032889 regulation of vacuole fusion, non-autophagic
Cellular Component
GO:0000015 phosphopyruvate hydratase complex
GO:0000324 fungal-type vacuole
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0005886 plasma membrane

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:2al1, PDBe:2al1, PDBj:2al1
PDBsum2al1
PubMed16309698
UniProtP00924|ENO1_YEAST Enolase 1 (Gene Name=ENO1)

[Back to BioLiP]