Structure of PDB 2aa6 Chain B

Receptor sequence
>2aa6B (length=259) Species: 9606 (Homo sapiens) [Search protein sequence]
ALVPQLSTISRALTPSPVMVLENIEPEIVYAGYDSSKPDTAENLLSTLNR
LAGKQMIQVVKWAKVLPGFKNLPLEDQITLIQYSWMSLLSFALSWRSYKH
TNSQFLYFAPDLVFNEEKMHQSAMYELCQGMHQISLQFVRLQLTFEEYTI
MKVLLLLSTIPKDGLKSQAAFEEMRTNYIKELRKMVTPNNSGQSWQRFYQ
LTKLLDSMHDLVSDLLEFCFYTFRESHALKVEFPAMLVEIISDQLPKVES
GNAKPLYFH
3D structure
PDB2aa6 A Ligand-mediated Hydrogen Bond Network Required for the Activation of the Mineralocorticoid Receptor
ChainB
Resolution1.95 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 STR B L769 N770 Q776 M807 L810 F829 M845 M852 F941 C942 T945 L48 N49 Q55 M86 L89 F108 M124 M131 F218 C219 T222 BindingDB: IC50=14nM,Kd=0.390000nM
External links
PDB RCSB:2aa6, PDBe:2aa6, PDBj:2aa6
PDBsum2aa6
PubMed15967794
UniProtP08235|MCR_HUMAN Mineralocorticoid receptor (Gene Name=NR3C2)

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