Structure of PDB 2a87 Chain B

Receptor sequence
>2a87B (length=304) Species: 1773 (Mycobacterium tuberculosis) [Search protein sequence]
RDVIVIGSGPAGYTAALYAARAQLAPLVFEGTSFGGALMTTTDVENYPGF
RNGITGPELMDEMREQALRFGADLRMEDVESVSLHGPLKSVVTADGQTHR
ARAVILAMGAAARYLQVPGEQELLGRGVSSCATCDGFFFRDQDIAVIGGG
DSAMEEATFLTRFARSVTLVHRRDEFRASKIMLDRARNNDKIRFLTNHTV
VAVDGDTTVTGLRVRDTNTGAETTLPVTGVFVAIGHEPRSGLVREAIDVD
PDGYVLVQGRTTSTSLPGVFAAGDLVDRTYRQAVTAAGSGCAAAIDAERW
LAEH
3D structure
PDB2a87 Conformational flexibility of Mycobacterium tuberculosis thioredoxin reductase: crystal structure and normal-mode analysis.
ChainB
Resolution3.0 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) F48 L52 D57 C145 C148 D149
Catalytic site (residue number reindexed from 1) F34 L38 D43 C131 C134 D135
Enzyme Commision number 1.8.1.9: thioredoxin-disulfide reductase.
Interaction with ligand
Gene Ontology
Molecular Function
GO:0004791 thioredoxin-disulfide reductase (NADPH) activity
GO:0005515 protein binding
GO:0015035 protein-disulfide reductase activity
GO:0016491 oxidoreductase activity
GO:0050660 flavin adenine dinucleotide binding
GO:0070402 NADPH binding
Biological Process
GO:0001666 response to hypoxia
GO:0019430 removal of superoxide radicals
GO:0045454 cell redox homeostasis
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2a87, PDBe:2a87, PDBj:2a87
PDBsum2a87
PubMed16301794
UniProtP9WHH1|TRXB_MYCTU Thioredoxin reductase (Gene Name=trxB)

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