Structure of PDB 2a1d Chain B

Receptor sequence
>2a1dB (length=259) Species: 9913 (Bos taurus) [Search protein sequence]
IVEGQDAEVGLSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTVDDLLVRIGKHSRTRYERKVEKISMLDKIYIHPRYNWKENLDRDI
ALLKLKRPIELSDYIHPVCLPDKQTAAKLLHAGFKGRVTGWGNRRETWTT
SVAEVQPSVLQVVNLPLVERPVCKASTRIRITDNMFCAGYKPGEGKRGDA
CEGDSGGPFVMKSPYNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWI
QKVIDRLGS
3D structure
PDB2a1d Structural Basis for Reduced Staphylocoagulase-mediated Bovine Prothrombin Activation
ChainB
Resolution3.5 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H57 D102 E192 G193 D194 S195 G196
Catalytic site (residue number reindexed from 1) H43 D99 E202 G203 D204 S205 G206
Enzyme Commision number 3.4.21.5: thrombin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 0G6 B H57 Y60A W60D L99 D189 A190 C191 S195 S214 W215 G216 G219 C220 H43 Y47 W50 L96 D199 A200 C201 S205 S226 W227 G228 G230 C231
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding
Biological Process
GO:0006508 proteolysis
GO:0007596 blood coagulation

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Molecular Function
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Biological Process
External links
PDB RCSB:2a1d, PDBe:2a1d, PDBj:2a1d
PDBsum2a1d
PubMed16230338
UniProtP00735|THRB_BOVIN Prothrombin (Gene Name=F2)

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