Structure of PDB 1zzr Chain B

Receptor sequence
>1zzrB (length=411) Species: 10116 (Rattus norvegicus) [Search protein sequence]
RFLKVKNWETDVVLTDTLHLKSTLETGCTEHICMGSIVLPVRTKDQLFPL
AKEFLDQYYSSIKRFGSKAHMDRLEEVNKEIESTSTYQLKDTELIYGAKH
AWRNASRCVGRIQWSKLQVFDARDCTTAHGMFNYICNHVKYATNKGNLRS
AITIFPQRTDGKHDFRVWNSQLIRYAGYKQPDGSTLGDPANVQFTEICIQ
QGWKAPRGRFDVLPLLLQANGNDPELFQIPPELVLEVPIRHPKFDWFKDL
GLKWYGLPAVSNMLLEIGGLEFSACPFSGWYMGTEIGVRNYCDNSRYNIL
EEVAKKMDLDMRKTSSLWKDQALVEINIAVLYSFQSDKVTIVDHHSATES
FIKHMENEYRCRGGCPADWVWIVPPMSGSITPVFHQEMLNYRLTPSFEYQ
PDPWNTHVWKG
3D structure
PDB1zzr Exploring the Binding Conformations of Bulkier Dipeptide Amide Inhibitors in Constitutive Nitric Oxide Synthases.
ChainB
Resolution2.05 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) C415 R418 W587 E592
Catalytic site (residue number reindexed from 1) C108 R111 W280 E285
Enzyme Commision number 1.14.13.39: nitric-oxide synthase (NADPH).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN B C326 C331 C28 C33
BS02 H4B B F691 H692 F384 H385
BS03 HEM B W409 R414 C415 G417 F584 G586 W587 E592 W678 F704 Y706 W102 R107 C108 G110 F277 G279 W280 E285 W371 F397 Y399
BS04 H4B B S334 R596 V677 W678 S36 R289 V370 W371
BS05 DP9 B Q478 S585 G586 W587 E592 Y706 Q171 S278 G279 W280 E285 Y399 MOAD: Ki=42uM
BindingDB: Ki=100nM,IC50=640nM
BS06 TFA B G417 Q420 G110 Q113
Gene Ontology
Molecular Function
GO:0004517 nitric-oxide synthase activity
GO:0020037 heme binding
Biological Process
GO:0006809 nitric oxide biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:1zzr, PDBe:1zzr, PDBj:1zzr
PDBsum1zzr
PubMed16285725
UniProtP29476|NOS1_RAT Nitric oxide synthase 1 (Gene Name=Nos1)

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