Structure of PDB 1zy7 Chain B

Receptor sequence
>1zy7B (length=362) Species: 9606 (Homo sapiens) [Search protein sequence]
SRQPIPSLHLPQVLADAVSRLVLGKFGDLTDNFSSPHARRKVLAGVVMTT
GTDVKDAKVISVSTGTKCINGEYMSDRGLALNDCHAEIISRRSLLRFLYT
QLELYLNNKDDQKRSIFQKSERGGFRLKENVQFHLYISTSPCGDARIFSP
HERKARGQLRTKIESGEGTIPVLLTMSCSDKIARWNVVGIQGSLLSIFVE
PIYFSSIILGSLYHGDHLSRAMYQRISNIEDLPPLYTLNKPLLSGISNAE
ARQPGKAPNFSVNWTVGDSAIEVINATTGKDELGRASRLCKHALYCRWMR
VHGKVPSHLLRSKITKPNVYHESKLAAKEYQAAKARLFTAFIKAGLGAWV
EKPTEQDQFSLT
3D structure
PDB1zy7 Inositol hexakisphosphate is bound in the ADAR2 core and required for RNA editing.
ChainB
Resolution1.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.5.4.37: double-stranded RNA adenine deaminase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN B H394 C451 C516 H85 C142 C178
BS02 IHP B N391 I397 R401 K519 R522 G530 S531 K629 Y658 K662 Y668 K672 E689 K690 N82 I88 R92 K181 R184 G192 S193 K291 Y320 K324 Y330 K334 E351 K352
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0004000 adenosine deaminase activity
Biological Process
GO:0006396 RNA processing

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Molecular Function
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Biological Process
External links
PDB RCSB:1zy7, PDBe:1zy7, PDBj:1zy7
PDBsum1zy7
PubMed16141067
UniProtP78563|RED1_HUMAN Double-stranded RNA-specific editase 1 (Gene Name=ADARB1)

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