Structure of PDB 1zy5 Chain B

Receptor sequence
>1zy5B (length=249) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]
SLRYASDFEEIAVLGQGAFGQVVKARNALDSRYYAIKKIRHTEEKLSTIL
SEVMLLASLNHQYVVRYYAAWLERRNFVKKSTLFIQMEYCENGTLYDLIH
SENLNQQRDEYWRLFRQILEALSYIHSQGIIHRDLKPMNIFIDESRNVKI
GDFGLGTAMYVATEVLHYNEKIDMYSLGIIFFEMIYPFSTGMERVNILKK
LRSVSIEFPPDFDDNKMKVEKKIIRLLIDHDPNKRPGARTLLNSGWLPV
3D structure
PDB1zy5 Structural Basis for Autoinhibition and Mutational Activation of Eukaryotic Initiation Factor 2{alpha} Protein Kinase GCN2
ChainB
Resolution2.0 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) D835 K837 N840 D853 T887
Catalytic site (residue number reindexed from 1) D134 K136 N139 D152 T157
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ANP B Q607 V613 E789 Y790 C791 D835 K837 F842 D853 Q16 V22 E88 Y89 C90 D134 K136 F141 D152
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:1zy5, PDBe:1zy5, PDBj:1zy5
PDBsum1zy5
PubMed15964839
UniProtP15442|GCN2_YEAST eIF-2-alpha kinase GCN2 (Gene Name=GCN2)

[Back to BioLiP]